What Is A 5 Panel Drug Test?
A 5 panel test checks for marijuana, cocaine, PCP, amphetamines, and opiates—the most commonly abused drugs in the U.S.
It’s the standard for workplace programs and DOT compliance.
Substances Detected in a 5 Panel Test
Marijuana (THC)
Remains the most common positive in drug testing and is still prohibited under federal law, even in states where recreational or medical use is legal.
Cocaine
Amphetamines
Opiates
Phencyclidine (PCP)
Is a hallucinogen known for its unpredictable and dangerous effects, making it critical to detect in safety-sensitive industries.
Options For 5 Panel Tests
5 Panel Test With Expanded Opiates
The expanded 5 panel test adds opioids like hydrocodone, oxycodone, hydromorphone, and oxymorphone. These became a DOT requirement in 2017 and give employers stronger protection against opioid misuse. The standard 5 panel is still an option when only the original five drugs are a concern or when budgets are limited.
5 Panel Test With Alcohol
For court-ordered or probationary testing, alcohol can be added to the standard 5 panel. This option screens for ethyl alcohol in urine and is a popular choice for individuals who need comprehensive reporting for legal purposes. While DOT testing prohibits alcohol from being included, this version is ideal when alcohol monitoring is part of compliance.
Multi-Panel Drug Tests
Rapid & Non-DOT Testing Options
Purchase Your 5 Panel Drug Test
Although most private employers in the United States have a variety of options when it comes to the type of drug test (4 panel drug test, 5 panel drug test, 7 panel drug test, 10 panel drug test, etc.), as well as the testing specimen (blood, urine, hair, or saliva), most stick with the industry standard 5 panel drug screening test. For that reason, unless you have the need to test for a specific substance that is not included in the five panel drug test, National Drug Screening recommends sticking with the: 5 Panel Drug Test or 5 Panel Drug Test with Expanded Opiates (DOT Like).
For the fastest service possible and immediate testing
frequently asked questions
How should someone prepare before taking a 5 panel drug test?
No special preparation is required. Arrive hydrated, avoid excessive water intake, and bring a valid photo ID.
Can a 5 panel drug test be used for legal or court purposes?
Yes. Many courts and probation programs accept 5 panel drug tests, but requirements vary by jurisdiction. Always confirm what test is required before ordering.
Who reviews and verifies the results of a lab-based drug test?
A certified Medical Review Officer (MRO) reviews all lab results to ensure accuracy and considers valid prescriptions before final reporting.
Can employers customize the drugs included in a 5 panel test?
Yes. While the standard 5 panel is fixed, employers often add substances (like expanded opiates, fentanyl, benzodiazepines, barbiturates, methadone or propoxyphene) depending on their workplace policy. When these additional drugs are added, it is no longer considered a 5 panel.
What happens if my 5 panel test comes back positive?
Lab-based results are reviewed by a Medical Review Officer (MRO). You may be contacted to provide proof of a valid prescription before results are finalized. If there is not legitimate medical explanation your test result will be positive. Employer policy will determine the consequences of the positive drug result.
What is the detection window for drugs in urine vs. hair testing?
Urine tests detect most drugs used within the past 2–7 days, while hair tests can show use up to 90 days back.
Do over-the-counter medications or prescriptions affect 5 panel test results?
Yes, some medications may trigger initial positives. A Medical Review Officer (MRO) reviews prescriptions to confirm legitimate use. A laboratory confirmed positive result will be reversed to negative when there is a verified medical explanation.